Lipase Activity With Increasing Intra-abdominal Fat in Women A Hepatic Lipase Gene Promoter Polymorphism Attenuates the Increase in Hepatic
نویسندگان
چکیده
High hepatic lipase (HL) activity is associated with an atherogenic lipoprotein profile of small, dense LDL particles and lower HDL2-C. Intra-abdominal fat (IAF) is positively associated with HL activity. A hepatic lipase gene (LIPC) promoter variant (G3A) is associated with lower HL activity, higher HDL2-C, and less dense LDL particles. To determine whether the LIPC promoter polymorphism acts independently of IAF to regulate HL, 57 healthy, premenopausal women were studied. The LIPC promoter A allele was associated with significantly lower HL activity (GA/AA5104634 versus GG5145657 nmoles z mL z min, P50.009). IAF was positively correlated with HL activity (r50.431, P,0.001). Multivariate analysis revealed a strong relationship between both the LIPC promoter genotype (P50.001) and IAF (P,0.001) with HL activity. The relationship between IAF and HL activity for carriers and noncarriers of the A allele was curvilinear with the carriers having a lower apparent maximum level of plasma HL activity compared with noncarriers (138 versus 218 nmoles z mL z min, P,0.001). In addition, the LIPC A allele was associated with a significantly higher HDL2-C (GA/AA51667 versus GG51165 mg/dL, P50.003). We conclude that the LIPC promoter A allele attenuates the increase in HL activity due to IAF in premenopausal women. (Arterioscler Thromb Vasc Biol. 1999;19:2701-2707.)
منابع مشابه
A hepatic lipase gene promoter polymorphism attenuates the increase in hepatic lipase activity with increasing intra-abdominal fat in women.
High hepatic lipase (HL) activity is associated with an atherogenic lipoprotein profile of small, dense LDL particles and lower HDL(2)-C. Intra-abdominal fat (IAF) is positively associated with HL activity. A hepatic lipase gene (LIPC) promoter variant (G-->A(-250)) is associated with lower HL activity, higher HDL(2)-C, and less dense LDL particles. To determine whether the LIPC promoter polymo...
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